Make sure you have installed the extension titletips!
Import from online repository and install t3xtooltip.
Add the extension-template from titletips and make sure that its not beeing cleared out later (PAGE-object!).
Add the extension-template from t3xtooltip to your template (AFTER css_styled_content and any other extension which takes control over styles.content.get*, because t3xtooltip uses the postUserFunc).
Create a new page (sysfolder).
Insert a new record: “Tooltip Definitions”.
Set constants “plugin.tx_t3xtooltip_pi1.PIDtooltip” to the PID of the sysfolder which contains your tooltip definitions (see TypoScript below).
If you want to style your tooltips with CSS, take a look at the typoscript of titletips.